Where Italian culinary artistry meets San Francisco sophistication, Acquerello San Francisco stands as a beacon of fine dining excellence beneath its signature vaulted wood-beam ceilings. Chef Suzette Gresham's two-Michelin-starred sanctuary has redefined luxury dining since 1989, transforming a historic Nob Hill chapel into one of the city's most revered gastronomic destinations.

Chef Gresham's remarkable journey spans over three decades at Acquerello, making her among the few female chefs in America to earn and maintain two Michelin stars. Her partnership with Giancarlo Paterlini began at The Donatello hotel before they opened Acquerello in Julia Morgan's architecturally stunning 1920s building. Under Gresham's leadership, this San Francisco fine dining institution has consistently earned critical acclaim, including Wine Spectator's Grand Award annually since 2012 and a permanent place among the Chronicle's Top 100 Bay Area Restaurants.

The cuisine embodies "simple elegance" through contemporary Italian dishes that honor tradition while embracing innovation. Gresham's multi-course prix fixe menus showcase signature creations like chilled Maine lobster with passion fruit and olio nuovo, Rossotti Ranch vitello tonnato with caper and Parmesan, and ridged pasta with faux foie gras, black truffle, and Marsala. The dry-aged Liberty duck with red wine cured sausage exemplifies her mastery of classic technique with personal flair. Optional supplements include N25 Reserve Oscietra caviar and A5 Wagyu beef, elevating the tasting menu experience to ultra-premium heights. Seasonal menus range from three to five courses, accommodating various dining preferences while maintaining unwavering quality standards.

The dining room's golden-etched wooden arches and dramatic floral arrangements create an atmosphere of timeless refinement without ostentation. Service reflects Gresham's commitment to nurturing talent, with expertly trained staff providing polished yet warm hospitality. The beverage program showcases one of America's most exceptional Piemonte-focused wine collections, complemented by an extensive international selection that perfectly accompanies each dish. The sommelier team serves as essential guides through this remarkable cellar, one of the deepest Italian wine and Champagne collections in the country.

Reservations at this best fine dining in San Francisco destination require advance planning, with the chef's table offering an intimate view of Gresham's culinary artistry. Acquerello reservations represent more than dinner—they're an invitation to experience decades of refined Italian gastronomy in San Francisco's most elegant setting.