Best Restaurants for Wine Lovers in St Louis
This list holds four Wine Spectator Best of Award of Excellence awards for 2026, at Blood & Sand in Downtown West, Annie Gunn's in Chesterfield, Casa Don Alfonso in Clayton, and Truflles in Acme Heights. Annie Gunn's and Truflles also hold a Star Wine List for the same year. Blood & Sand has one of the most diverse wine programs in St Louis, with a tasting menu. Annie Gunn's is sommelier-led. Truflles sets an exceptional list beside modern American steakhouse cooking.
Eleven Eleven Mississippi in Lafayette Square cooks Tuscan and Californian food and uses its own hydroponic greenhouse, with an exceptional, extensive list. Dominic's on The Hill serves traditional Italian fine dining and an extensive Italian-heavy list, named by Conde Nast Traveler one of the two best Italian restaurants in the country. Casa Don Alfonso in Clayton serves Southern Italian cooking and a tasting menu with a sommelier-led list.
How this list is chosen: Restaurants holding a Wine Spectator Restaurant Award or rated as having an exceptional wine program, listed alphabetically. Updated October 8, 2026.
Annie Gunn's
Wine Spectator Best of Award of Excellence · Exceptional wine program
A Chesterfield institution operating on the western edge of greater St Louis, Annie Gunn's holds a White Star recognition from Star Wine List, signalling a wine program that punches well above its suburban address.
Blood & Sand
Wine Spectator Best of Award of Excellence · Exceptional wine program
Blood & Sand occupies a handsome space at 1500 St Charles St in St. Louis, Missouri, placing it squarely in the city's more considered drinking and dining tier. The bar's name references one of the classic cocktail canon's more demanding recipes, signalling an intention that goes beyond the average pours. For St. Louis drinkers who follow craft-program depth, it warrants a look.
Casa Don Alfonso
Wine Spectator Best of Award of Excellence
Casa Don Alfonso gives Clayton a polished dining room in a St Louis market that often splits between steakhouse comfort, Italian-American familiarity, and newer specialist formats. Its value is in how it reframes sourcing and Southern Italian influence for a city where ingredient identity increasingly matters as much as occasion dining.
Dominic's
Exceptional wine program
One of St. Louis's most enduring Italian-American dining institutions, Dominic's on Wilson Avenue has shaped the city's fine dining expectations across multiple decades. Rooted in the traditions of Italian-American hospitality that defined Midwestern restaurant culture through the latter half of the twentieth century, it occupies a distinct position among St. Louis establishments where longevity and a defined point of view still carry serious weight.
Eleven Eleven Mississippi
Exceptional wine program
Eleven Eleven Mississippi anchors St. Louis's Cherokee Street corridor, a neighborhood whose identity has been shaped by successive waves of immigrant cooking and independent operators. The address alone signals where it stands in the city's dining conversation: south of downtown, embedded in a stretch that rewards repeat visits over one-time pilgrimage. A considered stop for anyone mapping the breadth of what St. Louis does well beyond its steakhouse reputation.
Truflles
Wine Spectator Best of Award of Excellence · Exceptional wine program
Truffles on Clayton Road holds a White Star recognition from Star Wine List, placing it among St Louis restaurants where the wine program carries real editorial weight. The Ladue corridor address signals a particular kind of Missouri dining: suburban in setting, serious in execution. For visitors building a St Louis table itinerary, it belongs in the conversation alongside the city's other destination addresses.
Planning restaurants for wine lovers in St Louis
- Which restaurants on this list hold a Wine Spectator award?
- Four restaurants on this list hold a Wine Spectator Best of Award of Excellence for 2026: Blood & Sand in Downtown West, Annie Gunn's in Chesterfield, Casa Don Alfonso in Clayton, and Truflles in Acme Heights. Annie Gunn's and Truflles also hold a Star Wine List for 2026.
- Which neighborhoods are the wine restaurants in?
- The six restaurants sit in Downtown West, Chesterfield, Clayton, Acme Heights, Lafayette Square, and The Hill. Blood & Sand is in Downtown West, Annie Gunn's in Chesterfield, Casa Don Alfonso in Clayton, Truflles in Acme Heights, Eleven Eleven Mississippi in Lafayette Square, and Dominic's on The Hill.
- How are the wine programs on this list characterized?
- Annie Gunn's in Chesterfield and Casa Don Alfonso in Clayton are sommelier-led, with extensive lists. Dominic's on The Hill has an extensive Italian-heavy list and an exceptional program. Blood & Sand in Downtown West has one of the most diverse wine programs in St Louis and an exceptional program. Truflles in Acme Heights and Eleven Eleven Mississippi in Lafayette Square also have exceptional programs and extensive lists.
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